Across TCGA patient cohorts, ALYREF mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALYREF-associated genes across cancer lineages are pDC, HSC, and Adipocytes. Each is linked with ALYREF in more than 2 cancer types. Because this analysis shows association rather than direction, both ALYREF-to-partner and partner-to-ALYREF results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALYREF→partner) and Y-score (partner→ALYREF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	pDC →	+0.042	+2.617	.019	.005	3	3
UCEC	HSC →	+0.110	+2.021	.006	.017	3	2
COAD	Adipocytes →	+0.041	+2.989	.013	.045	3	1
UCEC	Endothelial cells →	-0.033	-2.694	.017	<.001	3	1
UCEC	Astrocytes →	-0.035	-2.706	.038	.030	3	1
UCEC	lymphatic Endothelial cells →	-0.022	-2.194	.012	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

ALYREF survival (RNA) · tumor vs normal (RNA) · all ALYREF data types