Across TCGA cell cohorts, ALYREF mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ALYREF-associated genes across cancer lineages are OR4N5, TEX33, and ETDC. Each is linked with ALYREF in more than 1 cancer types. Because this analysis shows association rather than direction, both ALYREF-to-partner and partner-to-ALYREF results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALYREF→partner) and Y-score (partner→ALYREF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR4N5 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	TEX33 →	+0.036	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	ETDC →	+0.488	+5.228	<.001	.005	3	1
LARGE_INTESTINE	SPRR2F →	+0.477	+3.707	.006	.009	3	1
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

ALYREF survival (RNA) · tumor vs normal (RNA) · all ALYREF data types