ALS2

Across TCGA patient cohorts, ALS2 protein abundance is significantly associated with the RNA expression of many other genes, with 13,260 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ALS2-associated genes across cancer lineages are ABCB6, NCF1B, and TRAJ30. Each is linked with ALS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ALS2-to-partner and partner-to-ALS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ALS2 versus ABCB6 in GBM, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALS2→partner) and Y-score (partner→ALS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ABCB6 →	+0.402	+0.131	.002	.007	3	3
GBM	NCF1B →	-0.576	-0.138	<.001	<.001	3	3
CCRCC	TRAJ30 →	-1.008	-0.197	<.001	<.001	3	3
CCRCC	TIFAB →	-0.289	-0.133	.002	.002	3	3
COAD	IGLVI-70 →	-1.264	-0.876	.002	.003	3	3
BRCA	C6 →	+0.883	+0.169	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,260 associations by consensus.

ALS2 vs ABCB6 — GBM

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