ALS2

Across TCGA patient cohorts, ALS2 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALS2-associated genes across cancer lineages are eIF4E, ASNS, and ATM. Each is linked with ALS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALS2-to-partner and partner-to-ALS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ALS2-low versus ALS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALS2→partner) and Y-score (partner→ALS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.204	+1.874	<.001	<.001	3	3
COAD	ASNS →	+0.574	+3.459	<.001	.005	3	3
COAD	ATM →	-0.562	-1.691	<.001	.043	3	3
COAD	Caspase-7-cleavedD198 →	+1.225	+3.700	<.001	.001	3	3
COAD	Gab2 →	-0.284	-1.674	.023	.043	3	3
COAD	IRS1 →	-0.166	-2.213	.005	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

eIF4E by ALS2 expression — UCEC

Explore this box plot interactively →