ALS2

Across TCGA cell cohorts, ALS2 mutation is significantly associated with the RNA expression of many other genes, with 799 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALS2-associated genes across cancer lineages are TCP11X2, OBP2B, and GRK7. Each is linked with ALS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALS2-to-partner and partner-to-ALS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCP11X2 grouped by ALS2-low versus ALS2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALS2→partner) and Y-score (partner→ALS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TCP11X2 →	+0.132	+4.060	<.001	.003	3	3
BLOOD_Myeloma	OBP2B →	+0.126	+4.285	<.001	.003	3	2
LARGE_INTESTINE	GRK7 →	+0.078	+1.830	<.001	.004	3	2
LARGE_INTESTINE	ETFDH →	+0.689	+3.321	.002	.003	3	2
LARGE_INTESTINE	BEND3 →	+0.611	+3.321	<.001	.002	3	2
LARGE_INTESTINE	ARHGAP10 →	+0.880	+2.265	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 799 associations by consensus.

TCP11X2 by ALS2 expression — BLOOD_Leukemia

Explore this box plot interactively →