ALPP

Across TCGA pan-cancer cohorts, ALPP mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ALPP data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ALPP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ALPP expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LSCC, UCEC, and PDAC are the cancer types where ALPP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.576	0.949	.007	33	view →
UCEC	DFS	Tertile	All	1.000	0.817	.002	22	view →
PDAC	DFS	Median	II,III,IV	0.142	0.641	.031	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ALPP–LSCC (OS)

Open the LSCC breakdown →