ALPL

Across TCGA patient cohorts, ALPL protein abundance is significantly associated with the RNA expression of many other genes, with 10,613 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ALPL-associated genes across cancer lineages are FCN3, FPR1, and HP. Each is linked with ALPL in more than 4 cancer types. Because this analysis shows association rather than direction, both ALPL-to-partner and partner-to-ALPL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ALPL versus FCN3 in LSCC, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPL→partner) and Y-score (partner→ALPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FCN3 →	+1.558	+0.733	<.001	<.001	3	4
HNSC	FPR1 →	+1.241	+0.485	<.001	.004	2	5
LUAD	HP →	+2.011	+0.772	.005	.006	3	4
CCRCC	CD300H →	+0.536	+0.852	.002	<.001	3	4
LUAD	LINC02596 →	+0.407	+0.716	<.001	.002	3	4
LSCC	EIPR1 →	-0.500	-0.805	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,613 associations by consensus.

ALPL vs FCN3 — LSCC

Explore this scatter interactively →