ALPL

Across TCGA cell cohorts, ALPL mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ALPL-associated genes across cancer lineages are ECE2, OR4F4, and ANKRD34B. Each is linked with ALPL in more than 1 cancer types. Because this analysis shows association rather than direction, both ALPL-to-partner and partner-to-ALPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECE2 grouped by ALPL-low versus ALPL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPL→partner) and Y-score (partner→ALPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ECE2 →	+0.373	+4.054	<.001	.004	3	1
LARGE_INTESTINE	OR4F4 →	+0.028	+4.688	<.001	<.001	3	1
CNS	ANKRD34B →	+0.730	+3.727	<.001	.008	3	1
CNS	MPC1L →	+0.046	+3.201	.001	.008	3	1
CNS	KRTAP5-8 →	+0.055	+3.765	<.001	.008	3	1
LUNG_NSCLC_LUAD	TBC1D3H →	+0.849	+4.371	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ECE2 by ALPL expression — LARGE_INTESTINE

Explore this box plot interactively →