ALPL

Across TCGA cell cohorts, ALPL mutation is significantly associated with the mutation status of many other genes, with 1,339 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALPL-associated genes across cancer lineages are PDE3B, HJV, and PPP2R2B. Each is linked with ALPL in more than 2 cancer types. Because this analysis shows association rather than direction, both ALPL-to-partner and partner-to-ALPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDE3B grouped by ALPL-low versus ALPL-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPL→partner) and Y-score (partner→ALPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PDE3B →	+4.339	+4.339	.009	.009	1	3
CNS	HJV →	+5.000	+4.044	.008	.008	1	3
BLOOD_Lymphoma	PPP2R2B →	+6.014	+6.014	.001	.001	1	3
BLOOD_Lymphoma	TRIM27 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Lymphoma	DNAI3 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	PCDHGA1 →	+4.429	+5.247	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,339 associations by consensus.

PDE3B by ALPL expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →