Across TCGA patient cohorts, ALPK2 mutation is significantly associated with the total protein of many other genes, with 80 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALPK2-associated genes across cancer lineages are Cyclin-B1, FoxM1, and Caveolin-1. Each is linked with ALPK2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ALPK2-to-partner and partner-to-ALPK2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPK2→partner) and Y-score (partner→ALPK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.649	+2.152	<.001	<.001	3	5
LUSC	FoxM1 →	+0.319	+3.477	.003	.002	3	4
LUAD	Caveolin-1 →	-0.672	-2.459	.011	.017	3	3
LUAD	MYH11 →	-0.794	-3.169	.014	.018	3	3
UCEC	eIF4E →	+0.183	+1.788	<.001	<.001	3	3
UCEC	ACC1 →	+0.292	+1.180	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

Exploration

ALPK2 survival (RNA) · tumor vs normal (RNA) · all ALPK2 data types