Across TCGA cell cohorts, ALPK2 mutation is significantly associated with the RNA expression of many other genes, with 392 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALPK2-associated genes across cancer lineages are C2CD4D, PMM1, and BCAS2. Each is linked with ALPK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALPK2-to-partner and partner-to-ALPK2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPK2→partner) and Y-score (partner→ALPK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C2CD4D →	+0.114	+3.125	<.001	.008	3	2
LARGE_INTESTINE	PMM1 →	+0.574	+3.321	.003	.003	3	2
LARGE_INTESTINE	BCAS2 →	+0.616	+3.234	<.001	.004	3	2
LARGE_INTESTINE	TRAPPC8 →	+0.650	+2.628	<.001	.002	3	2
LARGE_INTESTINE	STARD4 →	+0.699	+2.459	.008	.006	3	2
LARGE_INTESTINE	SSMEM1 →	+0.016	+1.859	.003	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 392 associations by consensus.

Exploration

ALPK2 survival (RNA) · tumor vs normal (RNA) · all ALPK2 data types