ALOXE3

Across TCGA patient cohorts, ALOXE3 mutation is significantly associated with the RNA expression of many other genes, with 3,671 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALOXE3-associated genes across cancer lineages are KRTAP12-6P, ZNF736P7Y, and ONECUT1. Each is linked with ALOXE3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALOXE3-to-partner and partner-to-ALOXE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP12-6P grouped by ALOXE3-low versus ALOXE3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALOXE3→partner) and Y-score (partner→ALOXE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	KRTAP12-6P →	+0.128	+4.882	.001	.005	3	3
STAD	ZNF736P7Y →	+0.065	+4.206	.001	.003	3	3
COAD	ONECUT1 →	+0.200	+2.901	<.001	.008	3	3
UCEC	PPP2R2D →	+0.380	+2.606	<.001	<.001	3	3
UCEC	ZNF330 →	+0.362	+2.223	.004	<.001	3	3
UCEC	CKS2 →	+0.816	+3.058	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,671 associations by consensus.

KRTAP12-6P by ALOXE3 expression — LUSC

Explore this box plot interactively →