ALOX5AP

Across TCGA pan-cancer cohorts, ALOX5AP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ALOX5AP data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ALOX5AP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ALOX5AP expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

COAD, PDAC, and HNSC are the cancer types where ALOX5AP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.878	1.000	.017	54	view →
PDAC	DFS	Quartile	II,III,IV	0.254	0.531	<.001	36	view →
HNSC	OS	Median	All	0.906	0.776	.013	18	view →
LUAD	DFS	Median	II,III,IV	0.372	0.615	.048	2	view →
GBM	DFS	Median	All	0.652	0.778	.027	2	view →
UCEC	OS	Median	All	1.000	0.888	.021	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ALOX5AP–COAD (DFS)

Open the COAD breakdown →