ALOX5AP

Across TCGA patient cohorts, ALOX5AP protein abundance is significantly associated with the RNA expression of many other genes, with 17,926 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ALOX5AP-associated genes across cancer lineages are SPI1, MIR223HG, and SIGLEC7. Each is linked with ALOX5AP in more than 7 cancer types. Because this analysis shows association rather than direction, both ALOX5AP-to-partner and partner-to-ALOX5AP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ALOX5AP versus SPI1 in LSCC, with a Pearson correlation of 0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALOX5AP→partner) and Y-score (partner→ALOX5AP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPI1 →	+0.828	+0.679	<.001	<.001	3	8
GBM	MIR223HG →	+1.199	+0.782	<.001	<.001	3	8
GBM	SIGLEC7 →	+0.727	+0.687	<.001	<.001	3	7
CCRCC	NLRC4 →	+0.604	+0.616	<.001	<.001	3	7
LSCC	MYO1F →	+0.777	+0.807	<.001	<.001	3	7
GBM	FCGR2A →	+0.939	+0.777	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,926 associations by consensus.

ALOX5AP vs SPI1 — LSCC

Explore this scatter interactively →