ALOX5AP

Across TCGA patient cohorts, ALOX5AP mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALOX5AP-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and EGFR_pY1173. Each is linked with ALOX5AP in more than 1 cancer types. Because this analysis shows association rather than direction, both ALOX5AP-to-partner and partner-to-ALOX5AP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ALOX5AP-low versus ALOX5AP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALOX5AP→partner) and Y-score (partner→ALOX5AP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.084	-2.295	.033	.033	3	1
UCEC	EGFR_pY1068 →	-0.213	-2.584	.030	.010	3	1
UCEC	EGFR_pY1173 →	+0.064	+1.611	.041	.022	3	1
UCEC	Gab2 →	+0.357	+2.000	.010	.010	3	1
UCEC	ACVRL1 →	-0.114	-3.156	.032	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.169	-1.986	.010	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

14-3-3_beta by ALOX5AP expression — UCEC

Explore this box plot interactively →