ALOX15

Across TCGA pan-cancer cohorts, ALOX15 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ALOX15 data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ALOX15 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ALOX15 expression acts as an unfavorable survival marker.

LUAD, BRCA, and UCEC are the cancer types where ALOX15 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.111	0.750	<.001	29	view →
BRCA	OS	Median	III,IV	0.146	0.833	<.001	14	view →
UCEC	OS	Median	IV	0.066	0.755	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ALOX15–LUAD (OS)

Open the LUAD breakdown →