ALOX15

Across TCGA pan-cancer cohorts, ALOX15 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ALOX15 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ALOX15 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ALOX15 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where ALOX15 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.834	0.526	.012	10	view →
PDAC	DFS	Quartile	II,III,IV	0.551	0.282	.018	5	view →
HNSC	DFS	Median	IV	0.924	1.000	.037	2	view →
LSCC	OS	Tertile	All	1.000	0.806	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ALOX15–LUAD (OS)

Open the LUAD breakdown →