ALOX15

Across TCGA pan-cancer cohorts, ALOX15 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of ALOX15’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ALOX15 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ALOX15 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and PDAC are the cancer types where ALOX15 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ALOX15 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−0.415	<.001	10	view →
LUAD	Female	III,IV	−1.772	<.001	9	view →
PDAC	Female	All	+0.966	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

ALOX15–COAD

Open the COAD breakdown →