ALOX15

Across TCGA patient cohorts, ALOX15 mutation is significantly associated with the RNA expression of many other genes, with 996 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALOX15-associated genes across cancer lineages are LINC01177, CCND3P2, and RDM1P2. Each is linked with ALOX15 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALOX15-to-partner and partner-to-ALOX15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01177 grouped by ALOX15-low versus ALOX15-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALOX15→partner) and Y-score (partner→ALOX15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LINC01177 →	+0.158	+5.571	<.001	.002	3	2
BRCA	CCND3P2 →	+0.090	+6.342	<.001	<.001	3	2
BRCA	RDM1P2 →	+0.160	+4.436	<.001	.006	3	2
BRCA	LINC02098 →	+0.052	+5.016	<.001	.005	3	2
UCEC	ILKAP →	+0.378	+2.740	.002	.003	3	2
UCEC	TMEM62 →	+0.618	+3.000	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 996 associations by consensus.

LINC01177 by ALOX15 expression — BRCA

Explore this box plot interactively →