ALOX15

Across TCGA patient cohorts, ALOX15 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALOX15-associated genes across cancer lineages are Cyclin-E2, Notch1, and Caspase-7-cleavedD198. Each is linked with ALOX15 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALOX15-to-partner and partner-to-ALOX15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by ALOX15-low versus ALOX15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALOX15→partner) and Y-score (partner→ALOX15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.167	+3.169	.028	.018	3	3
UCEC	Notch1 →	+0.191	+2.000	.002	.032	3	2
UCEC	Caspase-7-cleavedD198 →	+0.849	+3.341	.001	.005	3	2
UCEC	Caspase-8 →	-0.241	-2.432	.033	.018	3	2
UCEC	EGFR_pY1068 →	-0.255	-2.321	.024	.034	3	1
UCEC	JNK2 →	+0.259	+3.807	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Cyclin-E2 by ALOX15 expression — UCEC

Explore this box plot interactively →