ALOX15

Across TCGA cell cohorts, ALOX15 mutation is significantly associated with the RNA expression of many other genes, with 101 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALOX15-associated genes across cancer lineages are RSPH6A, KAAG1, and DPPA2. Each is linked with ALOX15 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALOX15-to-partner and partner-to-ALOX15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RSPH6A grouped by ALOX15-low versus ALOX15-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALOX15→partner) and Y-score (partner→ALOX15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RSPH6A →	+0.028	+4.196	<.001	.001	3	1
CNS	KAAG1 →	+0.273	+3.479	.002	.009	3	1
CNS	DPPA2 →	+0.305	+3.643	<.001	.006	3	1
CNS	RLN3 →	+0.042	+3.459	<.001	.006	3	1
CNS	DEFB115 →	+0.131	+4.357	<.001	.004	3	1
LARGE_INTESTINE	GIMAP2 →	-1.009	-3.278	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 101 associations by consensus.

RSPH6A by ALOX15 expression — CNS

Explore this box plot interactively →