ALOX12B

Across TCGA pan-cancer cohorts, ALOX12B Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated ALOX12B data layer compared with 21 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ALOX12B Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ALOX12B expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

UCEC, LUAD, and KIRC are the cancer types where ALOX12B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.931	0.431	.009	22	view →
LUAD	OS	Median	II,III,IV	0.090	0.709	<.001	14	view →
KIRC	OS	Median	All	0.125	0.881	<.001	12	view →
LIHC	OS	Median	All	0.180	0.779	<.001	12	view →
STAD	DFS	Median	All	0.146	0.504	.029	9	view →
LUSC	DFS	Median	All	1.000	0.366	.015	9	view →
CESC	OS	Median	II,III,IV	0.203	0.759	.021	6	view →
PRAD	DFS	Median	All	0.117	0.776	<.001	6	view →
SARC	DFS	Median	All	0.081	0.632	<.001	3	view →
SKCM	DFS	Median	IV	1.000	0.201	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

ALOX12B–UCEC (DFS)

Open the UCEC breakdown →