ALMS1

Across TCGA pan-cancer cohorts, ALMS1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ALMS1 data layer compared with 20 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ALMS1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ALMS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, UCEC, and LSCC are the cancer types where ALMS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.820	0.312	.002	30	view →
UCEC	OS	Quartile	III,IV	0.280	1.000	.027	20	view →
LSCC	DFS	Median	All	0.678	0.910	.004	11	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
HNSC	DFS	Median	All	0.333	0.889	.014	7	view →
CCRCC	DFS	Median	All	0.917	0.668	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ALMS1–LUAD (OS)

Open the LUAD breakdown →