ALMS1

Across TCGA patient cohorts, ALMS1 mutation is significantly associated with the total protein of many other genes, with 86 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALMS1-associated genes across cancer lineages are ASNS, ATM, and Caspase-7-cleavedD198. Each is linked with ALMS1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ALMS1-to-partner and partner-to-ALMS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ALMS1-low versus ALMS1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALMS1→partner) and Y-score (partner→ALMS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ASNS →	+0.465	+2.000	.001	.028	3	5
UCEC	ATM →	-0.519	-1.584	<.001	<.001	3	5
STAD	Caspase-7-cleavedD198 →	+0.737	+3.459	.003	.004	2	5
STAD	c-Kit →	-0.247	-1.765	.021	.012	3	4
UCEC	4E-BP1 →	+0.255	+1.440	<.001	<.001	3	4
UCEC	Cyclin-B1 →	+0.610	+1.898	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

ASNS by ALMS1 expression — STAD

Explore this box plot interactively →