ALMS1

Across TCGA cell cohorts, ALMS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,561 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALMS1-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Regulation of centrosome cycle, and Regulation of metaphase/anaphase transition of cell cycle. Each is linked with ALMS1 in more than 18 cancer types. Because this analysis shows association rather than direction, both ALMS1-to-partner and partner-to-ALMS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by ALMS1-low versus ALMS1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALMS1→partner) and Y-score (partner→ALMS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of gene expression, epigenetic →	+0.087	+0.926	<.001	<.001	3	19
LUNG_SCLC	Regulation of centrosome cycle →	+0.142	+0.927	<.001	<.001	3	19
SOFT_TISSUE	Regulation of metaphase/anaphase transition of cell cycle →	+0.129	+1.147	<.001	<.001	3	19
LUNG_SCLC	Regulation of microtubule-based process →	+0.095	+0.975	<.001	<.001	3	19
SOFT_TISSUE	Mitotic sister chromatid segregation →	+0.140	+1.238	<.001	<.001	3	18
SOFT_TISSUE	Spindle organization →	+0.081	+0.998	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,561 associations by consensus.

Negative regulation of gene expression, epigenetic by ALMS1 expression — LUNG_SCLC

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