ALLC

Across TCGA patient cohorts, ALLC mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALLC-associated genes across cancer lineages are ERK2, PDCD4, and Shc_pY317. Each is linked with ALLC in more than 1 cancer types. Because this analysis shows association rather than direction, both ALLC-to-partner and partner-to-ALLC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ALLC-low versus ALLC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALLC→partner) and Y-score (partner→ALLC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.262	+2.415	<.001	.003	3	2
UCEC	PDCD4 →	-0.591	-2.459	.001	.018	3	2
UCEC	Shc_pY317 →	-0.200	-2.415	.001	.003	3	2
UCEC	STAT3_pY705 →	-0.326	-1.906	.001	.016	3	2
UCEC	Caspase-7-cleavedD198 →	+0.899	+2.019	<.001	.017	3	2
SKCM	FOXO3a →	-0.123	-3.169	.017	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

ERK2 by ALLC expression — UCEC

Explore this box plot interactively →