ALLC

Across TCGA cell cohorts, ALLC RNA expression is significantly associated with the go_rna of many other GO terms, with 817 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALLC-associated GO terms across cancer lineages are HRI-mediated signaling, Regulation of translation at presynapse, and Regulation of translation at presynapse, modulating synaptic transmission. Each is linked with ALLC in more than 3 cancer types. Because this analysis shows association rather than direction, both ALLC-to-partner and partner-to-ALLC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HRI-mediated signaling grouped by ALLC-low versus ALLC-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALLC→partner) and Y-score (partner→ALLC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	HRI-mediated signaling →	+0.101	+0.057	<.001	.004	3	4
BLOOD_Leukemia	Regulation of translation at presynapse →	+0.059	+0.035	.005	.001	3	4
BLOOD_Leukemia	Regulation of translation at presynapse, modulating synaptic transmission →	+0.059	+0.035	.005	.001	3	4
SOFT_TISSUE	Maintenance of organelle location →	+0.061	+0.160	<.001	.005	3	4
BLOOD_Leukemia	Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell →	-0.499	-0.036	.008	<.001	3	4
BLOOD_Leukemia	Myeloid leukocyte activation →	-0.059	-0.032	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 817 associations by consensus.

HRI-mediated signaling by ALLC expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →