ALLC

Across TCGA cell cohorts, ALLC mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALLC-associated genes across cancer lineages are NPVF, DEFB132, and MYF6. Each is linked with ALLC in more than 1 cancer types. Because this analysis shows association rather than direction, both ALLC-to-partner and partner-to-ALLC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPVF grouped by ALLC-low versus ALLC-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALLC→partner) and Y-score (partner→ALLC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NPVF →	+0.020	+5.285	<.001	.003	3	1
LUNG_SCLC	DEFB132 →	+0.012	+5.029	<.001	.006	3	1
BLOOD_Leukemia	MYF6 →	+0.169	+4.705	<.001	.003	3	1
BLOOD_Leukemia	AMELX →	+0.028	+4.539	<.001	.007	3	1
BLOOD_Leukemia	CBLN4 →	+0.004	+4.539	<.001	.007	3	1
LARGE_INTESTINE	L3MBTL4 →	+0.617	+3.285	.004	.007	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

NPVF by ALLC expression — STOMACH

Explore this box plot interactively →