ALKBH8

Across TCGA patient cohorts, ALKBH8 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALKBH8-associated genes across cancer lineages are ATM, eIF4E, and MEK1. Each is linked with ALKBH8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALKBH8-to-partner and partner-to-ALKBH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ALKBH8-low versus ALKBH8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH8→partner) and Y-score (partner→ALKBH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.435	-2.000	.033	.032	3	2
UCEC	eIF4E →	+0.199	+2.000	.036	.032	3	1
UCEC	MEK1 →	+0.382	+3.807	.020	<.001	3	1
UCEC	Notch1 →	+0.179	+3.179	.004	.010	3	1
UCEC	p62 Lck ligand →	+0.535	+3.469	<.001	.002	3	1
UCEC	PCNA →	+0.273	+2.700	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ATM by ALKBH8 expression — UCEC

Explore this box plot interactively →