ALKBH8

Across TCGA cell cohorts, ALKBH8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,195 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALKBH8-associated GO terms across cancer lineages are Meiotic sister chromatid cohesion, centromeric, Ether catabolic process, and Glycerol ether catabolic process. Each is linked with ALKBH8 in more than 16 cancer types. Because this analysis shows association rather than direction, both ALKBH8-to-partner and partner-to-ALKBH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Meiotic sister chromatid cohesion, centromeric grouped by ALKBH8-low versus ALKBH8-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH8→partner) and Y-score (partner→ALKBH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Meiotic sister chromatid cohesion, centromeric →	+0.127	+0.846	<.001	.001	3	17
OVARY	Ether catabolic process →	+0.173	+0.721	<.001	<.001	3	15
OVARY	Glycerol ether catabolic process →	+0.173	+0.721	<.001	<.001	3	15
OVARY	Platelet activating factor catabolic process →	+0.173	+0.721	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Mitotic nuclear division →	+0.095	+0.849	<.001	<.001	3	14
BREAST	Negative regulation of mitotic nuclear division →	+0.135	+0.770	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,195 associations by consensus.

Meiotic sister chromatid cohesion, centromeric by ALKBH8 expression — OVARY

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