ALKBH5

Across TCGA patient cohorts, ALKBH5 protein abundance is significantly associated with the RNA expression of many other genes, with 13,015 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible ALKBH5-associated genes across cancer lineages are RPA1, MED9, and PRPSAP2. Each is linked with ALKBH5 in more than 6 cancer types. Because this analysis shows association rather than direction, both ALKBH5-to-partner and partner-to-ALKBH5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ALKBH5 versus RPA1 in LSCC, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH5→partner) and Y-score (partner→ALKBH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RPA1 →	+0.855	+0.541	<.001	<.001	3	7
UCEC	MED9 →	+0.484	+0.267	<.001	.003	3	7
OV	PRPSAP2 →	+0.704	+0.373	<.001	<.001	3	7
HNSC	PDK1 →	+1.059	+0.420	<.001	<.001	3	7
UCEC	ATPAF2 →	+0.528	+0.361	<.001	<.001	3	7
HNSC	SHMT1 →	+0.737	+0.357	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,015 associations by consensus.

ALKBH5 vs RPA1 — LSCC

Explore this scatter interactively →