ALKBH5

Across TCGA patient cohorts, ALKBH5 mutation is significantly associated with the RNA expression of many other genes, with 592 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALKBH5-associated genes across cancer lineages are RN7SL147P, OR12D2, and SEC63P2. Each is linked with ALKBH5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALKBH5-to-partner and partner-to-ALKBH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL147P grouped by ALKBH5-low versus ALKBH5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH5→partner) and Y-score (partner→ALKBH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SL147P →	+0.585	+3.870	<.001	.006	3	3
CESC	OR12D2 →	+0.039	+5.418	.005	.005	3	2
UCEC	SEC63P2 →	+0.097	+2.515	<.001	.005	3	2
UCEC	RNA5SP419 →	+0.629	+2.398	.001	.007	3	2
UCEC	RNA5SP410 →	+0.570	+2.566	.003	.002	3	2
UCEC	RNU6-988P →	+0.403	+2.252	.006	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 592 associations by consensus.

RN7SL147P by ALKBH5 expression — COAD

Explore this box plot interactively →