ALKBH5

Across TCGA patient cohorts, ALKBH5 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALKBH5-associated genes across cancer lineages are ERK2, p70-S6K_pT389, and c-Jun_pS73. Each is linked with ALKBH5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALKBH5-to-partner and partner-to-ALKBH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ALKBH5-low versus ALKBH5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH5→partner) and Y-score (partner→ALKBH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.278	+3.321	.005	.010	3	1
UCEC	p70-S6K_pT389 →	-0.239	-2.990	.016	.036	2	1
UCEC	c-Jun_pS73 →	-0.214	-3.321	.010	.010	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ERK2 by ALKBH5 expression — UCEC

Explore this box plot interactively →