ALKBH5

Across TCGA cell cohorts, ALKBH5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,718 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALKBH5-associated GO terms across cancer lineages are Glycine biosynthetic process, Negative regulation of brown fat cell differentiation, and Positive regulation of transcription initiation by RNA polymerase II. Each is linked with ALKBH5 in more than 13 cancer types. Because this analysis shows association rather than direction, both ALKBH5-to-partner and partner-to-ALKBH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glycine biosynthetic process grouped by ALKBH5-low versus ALKBH5-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH5→partner) and Y-score (partner→ALKBH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Glycine biosynthetic process →	+0.215	+0.844	<.001	<.001	3	14
STOMACH	Negative regulation of brown fat cell differentiation →	+0.200	+0.853	.002	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Positive regulation of transcription initiation by RNA polymerase II →	+0.068	+0.889	<.001	<.001	3	13
BREAST	DTMP biosynthetic process →	+0.147	+0.660	.004	.005	2	13
BREAST	Pyrimidine deoxyribonucleoside monophosphate biosynthetic process →	+0.147	+0.660	.004	.005	2	13
OESOPHAGUS	Regulation of RNA export from nucleus →	+0.113	+1.139	.002	.005	1	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,718 associations by consensus.

Glycine biosynthetic process by ALKBH5 expression — BREAST

Explore this box plot interactively →