ALKBH5

Across TCGA cell cohorts, ALKBH5 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALKBH5-associated genes across cancer lineages are TIFAB, ZNF831, and TAFA1. Each is linked with ALKBH5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALKBH5-to-partner and partner-to-ALKBH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIFAB grouped by ALKBH5-low versus ALKBH5-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH5→partner) and Y-score (partner→ALKBH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TIFAB →	+0.012	+4.981	<.001	.008	3	1
LARGE_INTESTINE	ZNF831 →	+0.018	+4.273	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.410	+4.273	<.001	.006	3	1
LARGE_INTESTINE	CENPVL1 →	+0.227	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TIFAB by ALKBH5 expression — CNS

Explore this box plot interactively →