ALKBH5

Across TCGA cell cohorts, ALKBH5 mutation is significantly associated with the mutation status of many other genes, with 2,299 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALKBH5-associated genes across cancer lineages are CHRND, STRBP, and RNF151. Each is linked with ALKBH5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALKBH5-to-partner and partner-to-ALKBH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHRND grouped by ALKBH5-low versus ALKBH5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH5→partner) and Y-score (partner→ALKBH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CHRND →	+3.087	+4.392	.005	.005	1	3
LARGE_INTESTINE	STRBP →	+3.087	+4.392	.005	.005	1	3
LARGE_INTESTINE	RNF151 →	+5.672	+5.672	<.001	<.001	1	3
OVARY	OR10G7 →	+4.977	+4.415	.007	.007	1	3
OVARY	CEP72 →	+4.977	+4.415	.007	.007	1	3
OVARY	PRPF39 →	+4.977	+4.415	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,299 associations by consensus.

CHRND by ALKBH5 expression — LARGE_INTESTINE

Explore this box plot interactively →