Across TCGA cell cohorts, ALKBH2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALKBH2-associated genes across cancer lineages are C6orf118, SSMEM1, and SDR9C7. Each is linked with ALKBH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALKBH2-to-partner and partner-to-ALKBH2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH2→partner) and Y-score (partner→ALKBH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.122	+3.115	<.001	.004	3	1
LARGE_INTESTINE	SSMEM1 →	+0.023	+3.029	.001	.006	3	1
LARGE_INTESTINE	SDR9C7 →	+0.099	+3.333	.009	.009	3	1
LARGE_INTESTINE	PNMA3 →	+0.194	+2.781	<.001	.009	3	1
LARGE_INTESTINE	BPIFA1 →	+0.174	+3.103	<.001	.004	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.008	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

ALKBH2 survival (RNA) · tumor vs normal (RNA) · all ALKBH2 data types