ALKBH1

Across TCGA pan-cancer cohorts, ALKBH1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ALKBH1 data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ALKBH1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ALKBH1 expression acts as an unfavorable survival marker.

LSCC, HNSC, and GBM are the cancer types where ALKBH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	III,IV	0.526	0.938	.006	15	view →
HNSC	DFS	Median	All	0.623	1.000	.012	10	view →
GBM	OS	Median	All	0.284	0.475	.016	10	view →
LUAD	DFS	Tertile	All	0.282	0.889	.018	8	view →
PDAC	DFS	Median	II,III,IV	0.182	0.461	.004	8	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ALKBH1–LSCC (OS)

Open the LSCC breakdown →