ALKBH1

Across TCGA patient cohorts, ALKBH1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALKBH1-associated genes across cancer lineages are Cyclin-B1, eIF4E, and ERK2. Each is linked with ALKBH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALKBH1-to-partner and partner-to-ALKBH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ALKBH1-low versus ALKBH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH1→partner) and Y-score (partner→ALKBH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.507	+2.700	.045	.006	3	2
UCEC	eIF4E →	+0.210	+3.013	.027	.018	3	1
UCEC	ERK2 →	+0.190	+2.321	.028	.034	3	1
UCEC	FoxM1 →	+0.231	+2.700	.047	.006	3	1
UCEC	mTOR_pS2448 →	-0.154	-3.302	.021	.010	3	1
UCEC	mTOR →	-0.241	-2.000	<.001	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Cyclin-B1 by ALKBH1 expression — UCEC

Explore this box plot interactively →