ALKBH1

Across TCGA cell cohorts, ALKBH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,202 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALKBH1-associated GO terms across cancer lineages are Oxidative RNA demethylation, Regulation of mitochondrial gene expression, and tRNA wobble cytosine modification. Each is linked with ALKBH1 in more than 17 cancer types. Because this analysis shows association rather than direction, both ALKBH1-to-partner and partner-to-ALKBH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oxidative RNA demethylation grouped by ALKBH1-low versus ALKBH1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH1→partner) and Y-score (partner→ALKBH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Oxidative RNA demethylation →	+0.125	+0.636	<.001	<.001	3	18
BLOOD_Myeloma	Regulation of mitochondrial gene expression →	+0.087	+0.875	<.001	.004	3	14
LUNG_SCLC	tRNA wobble cytosine modification →	+0.092	+0.580	.003	<.001	2	12
BONE	tRNA wobble base modification →	+0.077	+0.744	.001	<.001	3	11
SKIN	snRNA metabolic process →	+0.048	+0.434	<.001	<.001	3	11
SKIN	RNA modification →	+0.048	+0.659	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,202 associations by consensus.

Oxidative RNA demethylation by ALKBH1 expression — BONE

Explore this box plot interactively →