Across TCGA pan-cancer cohorts, ALKAL2 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ALKAL2 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher ALKAL2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ALKAL2 expression acts as an unfavorable survival marker.

LIHC and CESC are the cancer types where ALKAL2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.128	0.783	.001	36	view →
CESC	DFS	Median	All	0.260	0.740	.042	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: ALKAL2 tumor-vs-normal RNA expression · all ALKAL2 data types