Across TCGA patient cohorts, ALKAL1 mutation is significantly associated with the RNA expression of many other genes, with 95 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALKAL1-associated genes across cancer lineages are TRAJ27, GUSBP17, and RN7SL392P. Each is linked with ALKAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALKAL1-to-partner and partner-to-ALKAL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKAL1→partner) and Y-score (partner→ALKAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRAJ27 →	+0.624	+4.372	.001	.007	3	2
COAD	GUSBP17 →	+0.182	+5.080	.002	.008	3	2
HNSC	RN7SL392P →	+0.117	+4.912	<.001	.005	3	2
UCEC	RN7SL470P →	+0.407	+3.694	<.001	.003	3	2
UCEC	RNU6-1318P →	+0.776	+4.358	<.001	.001	3	2
UCEC	H3P3 →	+0.467	+3.717	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

Exploration

ALKAL1 survival (RNA) · tumor vs normal (RNA) · all ALKAL1 data types