ALK

Across TCGA pan-cancer cohorts, ALK Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ALK data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ALK Mutation is associated with better overall survival. In most high-consensus cancer types, elevated ALK expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LIHC, and READ are the cancer types where ALK Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.951	0.448	.005	32	view →
LIHC	DFS	Median	All	0.058	0.531	<.001	12	view →
READ	DFS	Median	All	0.182	0.798	.010	9	view →
ESCA	OS	Median	II,III,IV	0.374	0.711	.009	6	view →
BLCA	DFS	Median	IV	0.164	0.473	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ALK–UCEC (OS)

Open the UCEC breakdown →