ALG8

Across TCGA pan-cancer cohorts, ALG8 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ALG8 data layer compared with 28 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher ALG8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ALG8 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

READ, LIHC, and LUAD are the cancer types where ALG8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.527	0.933	<.001	9	view →
LIHC	DFS	Median	All	0.101	0.543	.044	6	view →
LUAD	OS	Median	All	0.277	0.787	.022	3	view →
UCEC	DFS	Median	II,III,IV	0.908	0.442	.047	2	view →
SKCM	DFS	Median	All	0.775	0.197	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ALG8–READ (OS)

Open the READ breakdown →