ALG8

Across TCGA patient cohorts, ALG8 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALG8-associated genes across cancer lineages are eEF2, eIF4E, and EGFR_pY1068. Each is linked with ALG8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALG8-to-partner and partner-to-ALG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ALG8-low versus ALG8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG8→partner) and Y-score (partner→ALG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.294	+2.222	.014	.010	3	2
UCEC	eIF4E →	+0.140	+2.598	.048	.005	3	2
UCEC	EGFR_pY1068 →	-0.242	-1.584	.003	.009	3	1
UCEC	A-Raf_pS299 →	-0.110	-3.321	.005	.009	3	1
UCEC	ERK2 →	+0.197	+2.087	.002	.005	3	1
UCEC	HER2_pY1248 →	-0.196	-2.584	.028	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

eEF2 by ALG8 expression — UCEC

Explore this box plot interactively →