ALG8

Across TCGA cell cohorts, ALG8 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible ALG8-associated genes across cancer lineages are C14orf177, BTNL2, and ENPP6. Each is linked with ALG8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALG8-to-partner and partner-to-ALG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C14orf177 grouped by ALG8-low versus ALG8-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG8→partner) and Y-score (partner→ALG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	C14orf177 →	+0.020	+4.357	<.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	BTNL2 →	+0.117	+4.209	<.001	.006	3	2
LARGE_INTESTINE	ENPP6 →	+0.036	+3.793	.004	.007	3	2
LARGE_INTESTINE	OR5V1 →	+0.008	+4.437	<.001	.004	3	2
LUNG_NSCLC_LUAD	OCM2 →	+0.045	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	PRR23B →	+0.006	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

C14orf177 by ALG8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →