ALG6

Across TCGA cell cohorts, ALG6 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,164 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ALG6-associated GO terms across cancer lineages are DNA replication, Mitotic cell cycle checkpoint signaling, and Regulation of centrosome duplication. Each is linked with ALG6 in more than 12 cancer types. Because this analysis shows association rather than direction, both ALG6-to-partner and partner-to-ALG6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication grouped by ALG6-low versus ALG6-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG6→partner) and Y-score (partner→ALG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DNA replication →	+0.126	+0.898	<.001	<.001	3	13
BONE	Mitotic cell cycle checkpoint signaling →	+0.102	+1.023	.005	<.001	3	13
BLOOD_Myeloma	Regulation of centrosome duplication →	+0.116	+0.967	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication maintenance of fidelity →	+0.124	+1.093	<.001	<.001	3	12
LUNG_SCLC	Regulation of centrosome cycle →	+0.088	+0.659	<.001	<.001	3	12
BLOOD_Lymphoma	Maintenance of centrosome location →	+0.079	+0.837	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,164 associations by consensus.

DNA replication by ALG6 expression — BLOOD_Myeloma

Explore this box plot interactively →