ALG5

Across TCGA pan-cancer cohorts, ALG5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ALG5 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ALG5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ALG5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC, HNSC, and GBM are the cancer types where ALG5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.541	0.904	.008	17	view →
HNSC	DFS	Median	III,IV	0.906	1.000	.006	6	view →
GBM	OS	Quartile	All	0.560	0.812	.022	4	view →
PDAC	OS	Tertile	IV	0.222	0.905	.038	3	view →
LUAD	OS	Tertile	II,III,IV	0.461	0.892	.038	2	view →
CCRCC	OS	Quartile	All	1.000	0.834	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ALG5–LSCC (DFS)

Open the LSCC breakdown →