ALG5

Across TCGA cell cohorts, ALG5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,503 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALG5-associated GO terms across cancer lineages are Retrograde transport, vesicle recycling within Golgi, Mitochondrial translational termination, and Negative regulation of hematopoietic stem cell differentiation. Each is linked with ALG5 in more than 12 cancer types. Because this analysis shows association rather than direction, both ALG5-to-partner and partner-to-ALG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Retrograde transport, vesicle recycling within Golgi grouped by ALG5-low versus ALG5-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG5→partner) and Y-score (partner→ALG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Retrograde transport, vesicle recycling within Golgi →	+0.104	+0.519	<.001	<.001	3	13
LUNG_SCLC	Mitochondrial translational termination →	+0.105	+0.641	<.001	<.001	3	13
BLOOD_Myeloma	Negative regulation of hematopoietic stem cell differentiation →	+0.155	+0.892	.002	.008	3	12
BONE	Sister chromatid biorientation →	+0.160	+0.838	<.001	.001	3	11
LUNG_NSCLC_LUSC	Dolichol-linked oligosaccharide biosynthetic process →	+0.101	+0.904	.005	.002	2	11
BONE	Mitochondrial translational elongation →	+0.153	+1.085	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,503 associations by consensus.

Retrograde transport, vesicle recycling within Golgi by ALG5 expression — KIDNEY

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