Across TCGA cell cohorts, ALG3 mutation is significantly associated with the RNA expression of many other genes, with 813 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALG3-associated genes across cancer lineages are PRSS54, AVP, and PTH. Each is linked with ALG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALG3-to-partner and partner-to-ALG3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG3→partner) and Y-score (partner→ALG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRSS54 →	+0.043	+4.867	.001	.009	3	2
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	PTH →	+0.023	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	OR52K2 →	+0.012	+5.209	<.001	.005	3	1
BLOOD_Leukemia	CFC1 →	+0.019	+5.539	<.001	.003	3	1
BLOOD_Leukemia	GPR26 →	+0.077	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 813 associations by consensus.

Exploration

ALG3 survival (RNA) · tumor vs normal (RNA) · all ALG3 data types